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_x000D_ _x000D_ Usual Adult Dose for:_x000D_ Dysmenorrhea_x000D_ Osteoarthritis_x000D_ Rheumatoid Arthritis_x000D_ Pain_x000D_ Fever_x000D_ Usual Pediatric Dose for:_x000D_ Fever_x000D_ Pain_x000D_ Juvenile Rheumatoid Arthritis_x000D_ Patent Ductus Arteriosus_x000D_ Dysmenorrhea_x000D_ Additional dosage information:_x000D_ Renal Dose Adjustments_x000D_ Liver Dose Adjustments_x000D_ Precautions_x000D_ Dialysis_x000D_ Other Comments_x000D_ Usual Adult Dose for Dysmenorrhea_x000D_ 200 to 400 mg orally every 4 hours as needed_x000D_ Maximum dose: 3200 mg/day (prescription strength); 1200 mg/day (over-the-counter)_x000D_
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_x000D_ Comment:_x000D_ -Treatment should begin at the earliest onset of pain._x000D_ _x000D_ Use: For the relief of signs and symptoms of primary dysmenorrhea_x000D_ _x000D_ Usual Adult Dose for Osteoarthritis_x000D_ For minor pains of arthritis:_x000D_ Initial dose: 200 mg orally every 4 to 6 hours; may increase to 400 mg orally every 4 to 6 hours as needed_x000D_ Maximum dose: 1200 mg/day (over the counter)_x000D_ _x000D_ Rheumatoid Arthritis and Osteoarthritis (including flare-ups of chronic disease):_x000D_ 1200 to 3200 mg orally per day in divided doses 3 or 4 times a day_x000D_ -Individualize dose; adjust dose up or down depending on severity of symptoms_x000D_ Maximum dose: 3200 mg/day (prescription strength)_x000D_ _x000D_ Comments:_x000D_ -Patients with rheumatoid arthritis generally require higher doses than those with osteoarthritis._x000D_ -In chronic conditions, a therapeutic response may be seen in a few days to a week but most often is observed by 2 weeks; after a satisfactory response has been achieved, review and adjust dose to achieve the lowest dose that yields acceptable control._x000D_ -Individual patients may show a better response to 3200 mg/day compared with 2400 mg/day, although in well-controlled clinical trials, use of 3200 mg/day did not show a better mean response in terms of efficacy._x000D_ _x000D_ Use: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis_x000D_ _x000D_
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Usual Adult Dose for Rheumatoid Arthritis
_x000D_ For minor pains of arthritis:_x000D_ Initial dose: 200 mg orally every 4 to 6 hours; may increase to 400 mg orally every 4 to 6 hours as needed_x000D_ Maximum dose: 1200 mg/day (over the counter)_x000D_ _x000D_ Rheumatoid Arthritis and Osteoarthritis (including flare-ups of chronic disease):_x000D_ 1200 to 3200 mg orally per day in divided doses 3 or 4 times a day_x000D_ -Individualize dose; adjust dose up or down depending on severity of symptoms_x000D_ Maximum dose: 3200 mg/day (prescription strength)_x000D_ _x000D_ Comments:_x000D_ -Patients with rheumatoid arthritis generally require higher doses than those with osteoarthritis._x000D_ -In chronic conditions, a therapeutic response may be seen in a few days to a week but most often is observed by 2 weeks; after a satisfactory response has been achieved, review and adjust dose to achieve the lowest dose that yields acceptable control._x000D_ -Individual patients may show a better response to 3200 mg/day compared with 2400 mg/day, although in well-controlled clinical trials, use of 3200 mg/day did not show a better mean response in terms of efficacy.
