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_x000D_ Best place to buy Midazolam online/ Excipient: Contains 1.96 mg sodium (as sodium chloride) per ml of solution for injection or infusion._x000D_ _x000D_ For a full list of excipients, see section 6.1_x000D_ _x000D_
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_x000D_ _x000D_ Solution for Injection or Infusion._x000D_ _x000D_ Clear, colorless to pale yellow solution with a pH in the range of 2.9-3.7 and 170 mOsm/kg to 230 mOsm/kg osmolality._x000D_ _x000D_ _x000D_
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_x000D_ _x000D_ STANDARD DOSAGE_x000D_ _x000D_ Where can i buy Midazolam online ? Midazolam is a potent sedative agent that requires titration and slow administration. Titration is strongly recommended to safely obtain the desired level of sedation according to the clinical need, physical status, age and concomitant medication. In adults over 60 years, debilitated or chronically ill patients and paediatric patients, dose should be determined with caution and risk factors related to each patient should be taken into account. Standard dosages are provided in the table below._x000D_
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| Indication | Adults < 60 y | Adults ? 60y / debilitated or chronically ill | Children |
| Conscious sedation | i.v._x000D_ _x000D_ Initial dose: 2 – 2.5 mg_x000D_ _x000D_ Titration doses: 1 mg_x000D_ _x000D_ Total dose: 3.5–7.5 mg | i.v._x000D_ _x000D_ Initial dose: 0.5–1 mg_x000D_ _x000D_ Titration doses: 0.5–1 mg_x000D_ _x000D_ Total dose: <3.5 mg | i.v. in patients 6 months–5 years_x000D_ _x000D_ Initial dose: 0.05–0.1 mg/kg_x000D_ _x000D_ Total dose: < 6 mg_x000D_ _x000D_ i.v. in patients aged 6–12 years_x000D_ _x000D_ Initial dose: 0.025–0.05 mg/kg_x000D_ _x000D_ Total dose: <10 mg_x000D_ _x000D_ rectal > 6 months_x000D_ _x000D_ 0.3–0.5 mg/kg_x000D_ _x000D_ i.m. 1–15 years_x000D_ _x000D_ 0.05–0.15 mg/kg |
| Anaesthesia premedication | i.v._x000D_ _x000D_ 1-2 mg repeated_x000D_ _x000D_ i.m._x000D_ _x000D_ 0.07–0.1 mg/kg | i.v._x000D_ _x000D_ Initial dose: 0.5mg_x000D_ _x000D_ Slow uptitration as needed_x000D_ _x000D_ i.m._x000D_ _x000D_ 0.025–0.05 mg/kg | rectal > 6 months_x000D_ _x000D_ 0.3–0.5 mg/kg_x000D_ _x000D_ i.m. 1–15 years_x000D_ _x000D_ 0.08–0.2 mg/kg |
| Anaesthesia induction | i.v._x000D_ _x000D_ 0.15–0.2 mg/kg_x000D_ _x000D_ (0.3–0.35 without premedication) | i.v._x000D_ _x000D_ 0.05-0.15 mg/kg_x000D_ _x000D_ (0.15–0.3 without premedication) | |
| Sedative component in combined anaesthesia | i.v._x000D_ _x000D_ Intermittent doses of 0.03–0.1 mg/kg or continuous infusion of 0.03–0.1 mg/kg/h | i.v._x000D_ _x000D_ lower doses than recommended for adults <60 years | |
| Sedation in ICU | i.v._x000D_ _x000D_ Loading dose: 0.03–0.3 mg/kg in increments of 1–2.5 mg_x000D_ _x000D_ Maintenance dose: 0.03–0.2 mg/kg/h | i.v. in pre-term new-born infants <32 weeks gestational age_x000D_ _x000D_ 0.03 mg/kg/h_x000D_ _x000D_ i.v. in new-born infants >32 weeks and children up to 6 months_x000D_ _x000D_ 0.06 mg/kg/h_x000D_ _x000D_ i.v. in patients > 6 months of age_x000D_ _x000D_ Loading dose: 0.05–0.2 mg/kg_x000D_ _x000D_ Maintenance dosage: 0.06–0.12 mg/kg/h | |
_x000D_ CONSCIOUS SEDATION DOSAGE_x000D_ _x000D_ For conscious sedation prior to diagnostic or surgical intervention, midazolam is administered i.v. The dose must be individualised and titrated, and should not be administered by rapid or single bolus injection. The onset of sedation may vary individually depending on the physical status of the patient and the detailed circumstances of dosing (e.g. speed of administration, amount of dose). If necessary, subsequent doses may be administered according to the individual need. The onset of action is about 2 minutes after the injection. Maximum effect is obtained in about 5 to 10 minutes._x000D_ _x000D_ Adults_x000D_ _x000D_ The intravenous injection of midazolam should be given slowly, at a rate of approx. 1 mg/30 seconds._x000D_ _x000D_ Adults below the age of 60_x000D_ _x000D_ In adults below the age of 60 the initial dose is 2 to 2.5 mg given 5 to 10 minutes before the beginning of the procedure. Further doses of 1 mg may be given as necessary. Mean total doses have been found to range from 3.5 to 7.5 mg. A total dose greater than 5 mg is usually not necessary._x000D_ _x000D_ Adults over 60 years of age_x000D_ _x000D_ In adults over 60 years of age, debilitated or chronically ill patients, the initial dose must be reduced to 0.5-1.0 mg and given 5-10 minutes before the beginning of the procedure. Further doses of 0.5 to 1 mg may be given as necessary. Since in these patients the peak effect may be reached less rapidly, additional midazolam should be titrated very slowly and carefully. A total dose greater than 3.5 mg is usually not necessary._x000D_ _x000D_ Children_x000D_ _x000D_ I.V. administration: midazolam should be titrated slowly to the desired clinical effect. The initial dose of midazolam should be administered over 2 to 3 minutes. One must wait an additional 2 to 5 minutes to fully evaluate the sedative effect before initiating a procedure or repeating a dose. If further sedation is necessary, continue to titrate with small increments until the appropriate level of sedation is achieved. Infants and young children less than 5 years of age may require substantially higher doses (mg/kg) than older children and adolescents._x000D_ _x000D_ • Paediatric patients less than 6 months of age: paediatric patients less than 6 month of age are particularly vulnerable to airway obstruction and hypoventilation. For this reason, the use in conscious sedation in children less than 6 months of age is not recommended._x000D_ _x000D_ • Paediatric patients 6 months to 5 years of age: initial dose 0.05 to 0.1 mg/kg. A total dose up to 0.6 mg/kg may be necessary to reach the desired endpoint, but the total dose should not exceed 6 mg. Prolonged sedation and risk of hypoventilation may be associated with the higher doses._x000D_ _x000D_ • Paediatric patients 6 to 12 years of age: initial dose 0.025 to 0.05 mg/kg. A total dose of up to 0.4 mg/kg to a maximum of 10 mg may be necessary. Prolonged sedation and risk of hypoventilation may be associated with the higher doses._x000D_ _x000D_ • Paediatric patients 12 to 16 years of age: should be dosed as adults._x000D_ _x000D_ Rectal administration: the total dose of midazolam usually ranges from 0.3 to 0.5 mg/kg. Rectal administration of the ampoule solution is performed by means of a plastic applicator fixed on the end of the syringe. If the volume to be administered is too small, water may be added up to a total volume of 10 ml. Total dose should be administered at once and repeated rectal administration avoided._x000D_ _x000D_ The use in children less than 6 months of age is not recommended, as available data in this population are limited._x000D_ _x000D_ Deep i.m. administration: the doses used range between 0.05 and 0.15 mg/kg. A total dose greater than 10.0 mg is usually not necessary. This route should only be used in exceptional cases. Rectal administration should be preferred as i.m. injection is painful._x000D_ _x000D_ In children less than 15 kg of body weight, midazolam solutions with concentrations higher than 1mg/ml are not recommended. Higher concentrations should be diluted to 1mg/ml._x000D_ _x000D_ ANAESTHESIA DOSAGE_x000D_ _x000D_ Premedication_x000D_ _x000D_ Premedication with midazolam given shortly before a procedure produces sedation (induction of sleepiness or drowsiness and relief of apprehension) and preoperative impairment of memory._x000D_ _x000D_ Midazolam can also be administered in combination with anticholinergics. For this indication midazolam should be administered i.v. or i.m., deep into a large muscle mass 20 to 60 minutes before induction of anaesthesia), or preferably via the rectal route in children (see below). Close and continuous monitoring of the patients after administration of premedication is mandatory as interindividual sensitivity varies and symptoms of overdose may occur._x000D_ _x000D_ Adults_x000D_ _x000D_ For preoperative sedation and to impair memory of preoperative events, the recommended dose for adults of ASA Physical Status I & II and below 60 years is 1-2 mg i.v. repeated as needed, or 0.07 to 0.1 mg/kg administered deep i.m. The dose must be reduced and individualised when midazolam is administered to adults over 60 years of age, debilitated, or chronically ill patients. The recommended initial i.v. dose is 0.5 mg and should be slowly up titrated as needed. A dose of 0.025 to 0.05 mg/kg administered deep i.m. is recommended. In case of concomitant administration of narcotics the midazolam dose should be reduced. The usual dose is 2 to 3 mg._x000D_ _x000D_ Paediatric Patients_x000D_ _x000D_ New born infants and children up to 6 months of age:_x000D_ _x000D_ The use in children less than 6 months of age is not recommended as available data are limited._x000D_ _x000D_ Children over 6 months of age_x000D_ _x000D_ Rectal administration: The total dose of midazolam, usually ranging from 0.3 to 0.5 mg/kg should be administered 15 to 30 minutes before induction of anaesthesia. Rectal administration of the ampoule solution is performed by means of a plastic applicator fixed on the end of the syringe. If the volume to be administered is too small, water may be added up to a total volume of 10 ml._x000D_ _x000D_ Deep i.m. administration: As deep i.m. injection is painful, this route should only be used in exceptional cases. Rectal administration should be preferred. However, a dose range from 0.08 to 0.2 mg/kg of midazolam administered deep i.m. has been shown to be effective and safe. In children between ages 1 and 15 years, proportionally higher doses are required than in adults in relation to body-weight._x000D_ _x000D_ In children less than 15kg of body weight, midazolam solutions with concentrations higher than 1mg/ml are not recommended. Higher concentrations should be diluted to 1mg/ml._x000D_ _x000D_ INDUCTION_x000D_ _x000D_ Adults_x000D_ _x000D_ If midazolam is used for induction of anaesthesia before other anaesthetic agents have been administered, the individual response is variable. The dose should be titrated to the desired effect according to the patient’s age and clinical status. When midazolam is used before or in combination with other i.v. or inhalation agents for induction of anaesthesia, the initial dose of each agent should be significantly reduced, at times to as low as 25% of the usual initial dose of the individual agents._x000D_ _x000D_ The desired level of anaesthesia is reached by stepwise titration. The i.v. induction dose of midazolam should be given slowly in increments. Each increment of not more than 5 mg should be injected over 20 to 30 seconds allowing 2 minutes between successive increments._x000D_ _x000D_ • Premedicated adults below the age of 60 years_x000D_ _x000D_ In premedicated adults below the age of 60 years, an intravenous dose of 0.15–0.2 mg/kg will generally suffices._x000D_ _x000D_ • Non-premedicated adults below the age of 60_x000D_ _x000D_ In non-premedicated adults below the age of 60 the dose may be higher (0.3 to 0.35 mg/kg i.v.). If needed to complete induction, increments of approximately 25% higher of the patient’s initial dose may be used. Induction may instead be completed with inhalational anaesthetics. In resistant cases, a total dose of up to 0.6 mg/kg may be used for induction, but such larger doses may prolong recovery._x000D_ _x000D_ • Premedicated adults over 60 years of age, debilitated or chronically ill patients_x000D_ _x000D_ The dose should significantly be reduced, e.g., down to 0.05- 0.15 mg/kg administered i.v. over 20- 30 seconds and allowing 2 minutes for effect._x000D_ _x000D_ • Non-premedicated adults over 60 years of age_x000D_ _x000D_ Non-premedicated adults over 60 years of age usually require more midazolam for induction; an initial dose of 0.15 to 0.3 mg/kg is recommended. Non-premedicated patients with severe systemic disease or other debilitation usually require less midazolam for induction. An initial dose of 0.15 to 0.25 mg/kg will usually suffice._x000D_ _x000D_
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